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Kaushik S, Cuervo AM

Similarly, in non-human primates, the GLP-1R mRNA and protein expression present similar distribution in the CNS to rodents [75]

The impact of SGLT2 inhibitors on aldosterone and GLP-1 receptor agonists on aldosterone and testosterone has been evaluated, but a high level of evidence is still lacking

We adjusted for patient age, sex, race, ethnicity, Social Vulnerability Index quintile, starting BMI, weight change after treatment, history of insulin usage, and starting HbA1c

26,59,60 SGLT2i has the potential to treat MASH through four main mechanisms: decreasing hepatic de novo lipogenesis by lowering insulin levels, increasing fatty acid -oxidation by stimulating glucagon secretion, suppressing glucose-induced oxidative stress, and inhibiting liver fibrosis by lowering transforming growth factor-beta levels

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