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Authors contributions BG, JCL, and LAV participated in the concept and drafting of the manuscript, and performed the critical review for intellectual content

conducted a randomized controlled trial in obese older adults with cardiovascular or metabolic conditions, comparing three intervention groups: caloric restriction alone (WL), caloric restriction combined with aerobic training (WL + AT), and caloric restriction combined with resistance training (WL + RT)

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benefit analysis in long-term therapy DPP-4 inhibitors are a safe and well-tolerated drug class, ideal for older adults, type 2 diabetes patients, and those with kidney manifestations

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