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BMC Pediatr 2018;18(1):7

In further analyses, we included calendar year in the propensity score and estimated calendar time specific propensity scores (with the estimation of the scores stratified by calendar time period in four year intervals and country)

The body appears to adapt to both the delayed gastric emptying effects and the central nervous system appetite-suppressing signals, resulting in reduced nausea, vomiting, and other GI symptoms even as doses increase to therapeutic levels

But its a good reminder to stick with lower doses next time and only increase gradually if needed

doi: 10.1056/NEJMoa1901118 55 RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al

The findings have raised alarm among eating disorder charities, which have warned that weight-loss medications should only be sold under the strictest conditions