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Many individuals with hypothyroidism experience weight gain as a symptom, making concurrent use of these medications clinically relevant

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10.2337/dc10-1949

Centrally, these medications may affect brain appetite centers through multiple pathways, including signaling via vagal afferents and action on circumventricular organs (brain regions with a more permeable blood-brain barrier)

[DOI] [PMC free article] [PubMed] [Google Scholar] Mller et al