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Tirzepatide is a synthetic GLP-1 RA (receptor agonist)

Beyond pancreatic actions, GLP-1RAs exert direct effects in the hypothalamus and brainstem to regulate satiety and food intake, as well as gastrointestinal effects that slow nutrient absorption, contributing to postprandial glucose control [23,24]

At the time of its approval, the most common diabetes drugs were metformin and insulin

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Daniel Drucker joined the Habener laboratory in 1984

This is the not-so-secret secret, Collingwood says
