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Bager JE, Manhem K, Andersson T, et al

Tell your doctor if you have or have ever had kidney or pancreas disease, a history of diabetic retinopathy or any stomach problems such as difficulty digesting food

Researchers tracking how long does it take for tirzepatide to work should monitor glucose levels closely if using a niacinamide-containing formulation

Talk to your prescriber about all potential health risks before you start a new medication

Reduction in weight would need to be assessed for a longer period and in a larger cohort to determine sustainability of effect, alongside long-term safety and glycemic and other metabolic outcomes

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