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11 DESCRIPTION OZEMPIC (semaglutide) injection, for subcutaneous use, contains semaglutide, a human GLP-1 receptor agonist (or GLP-1 analog)

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It may have a slightly lower rate of serious infections compared to other biologic DMARDs (Schur & Cohen, 2014) twice weekly sc maintenance dosing due to its short half-life Adalimumab a recombinant 100% human IgG1 monoclonal antibody specific for TNF- similar efficacy as methotrexate (Schur & Cohen, 2014) can be given s.c

Zhong Q, Bollag RJ, Dransfield DT, Gasalla-Herraiz J, Ding KH, Min L, Isales CM (2000) Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells