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Unlike the current widely used medications such as Ozempic and Mounjaro that target the GLP-1 pathway alone, retatrutide, known as a GLP-3, targets three pathways related to metabolism: GIP, GLP-1, and glucagon

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Fibrosis, characterised by the excessive deposition of extracellular matrix via activated fibroblasts, is a pathological feature of several chronic inflammatory disorders, which collectively contribute significantly to global morbidity and mortality