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Concurrently, clinicians have observed increased conception rates among individuals using GLP-1 RAs, prompting investigation into whether these effects stem from improved metabolic health or direct pharmacologic influences on reproductive physiology

New triple receptor agonists have recently been designed and have shown a prolonged duration of action, supporting the possibility of once-weekly administration in humans

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Studies have demonstrated that both acne vulgaris (AV) and hidradenitis suppurativa (HS) share inflammatory pathways that result in immune system dysregulation through enhanced activity of IL-1, TNF-, and IL-17 pathways leading to follicular occlusion along with neutrophilic inflammation and abnormal keratinocyte proliferation [8]