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Stopping GLP-1 therapy often leads to weight rebound Most practitioners report that discontinuing GLP-1 therapy results in significant weight regain

Many users simply cannot eat enough in a six-hour window when appetite is pharmacologically blunted

Abbreviations: R, randomized

Patients may receive follow-up guidance to ensure therapy remains appropriate and effective

Patients taking insulin or sulfonylureas alongside tirzepatide need particular attention to avoid hyperglycemia when stopping

[1] Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron