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glp 1 origin GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] History of GLP-1: From Discovery
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doi: 10.1016/j.jaip.2024.05.002
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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Lemos JA
![glp 1 origin GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] History of GLP-1: From Discovery](https://revolutionhealth.org/cdn/shop/articles/What_is_GLP-1_9e9d1b41-2be6-410c-bc3a-855652d1bef7.png?v=1768865020&width=1100)
Robert Kushner, thanks so much for joining us today
![glp 1 origin GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] History of GLP-1: From Discovery](https://www.mdpi.com/ijms/ijms-25-03832/article_deploy/html/images/ijms-25-03832-g001-550.jpg)
Semaglutide & Tirzepatide is most effective when combined with healthy lifestyle changes, including diet and exercise
![glp 1 origin GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] History of GLP-1: From Discovery](https://www.apexanesthesia.com/wp-content/uploads/2024/05/article_GLP1_organ_effects.jpg)
That's why I wanted to take a careful , evidence-based look at it
![glp 1 origin GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] History of GLP-1: From Discovery](https://s3.amazonaws.com/production.scholastica/public/attachments/bd59d6e4-c76b-4a0f-853f-f18e54c05fbd/small/figure_2._principal_mechanisms_lead_by_glp-1r_activation.png)
When glucose is transported into the -cell, its metabolism generates ATP, which provides energy for the closure of K ATP channels and consequently an increase in intracellular calcium
![glp 1 origin GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] History of GLP-1: From Discovery](https://journals.physiology.org/cms/10.1152/physrev.00034.2006/asset/images/medium/z9j0040724440006.jpeg)