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Even if significant dose volume adjustments are necessary to effectively treat the new condition with a different route of administration and/or dosing, the imputed price (at parity price/unit with the first indication) may not be sufficient to realize the difference in value in the new indication due to higher disease burden, unmet need, or efficacy

For individuals with obesity, type 2 diabetes, or cardiovascular risk factors, the documented benefits of GLP-1 medications on weight, blood sugar, cardiovascular outcomes, and in some cases kidney and liver health are substantial

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