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N = 161,798 after matching GLP-1RA vs diet/exercise consultation Median follow-up: 2 years Key result: Any obesity-associated cancer HR 0.59, 95% CI 0.53-0.67 Site-specific signals: Multiple myeloma HR 0.37 Pancreatic cancer HR 0.40 Endometrial cancer HR 0.42 Colorectal cancer HR 0.49 But remember: This is observational

Most people lose 12 pounds per week on semaglutide, translating to 48 pounds monthly in the first phase of treatment

In a trial, people lost 75% fat and 25% muscle.

Orlistat (Alli) is the only OTC option

Neoepitopes were identified in DS and DP semaglutide follow-ons, indicating potential immunogenicity

Reconstitute using standard laboratory peptide protocols