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Human GPR17 long isoform regulation of GLP-1 secretion is not dependent on Gq-mediated signaling in GLUTag cells The Gq signaling inhibitor, YM-254890, was used to test the role of hGPR17L-mediated Gq signaling on GLP-1 secretion

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Due to the high prevalence of prediabetic hyperglycemia and diabetes mellitus (DM) in pancreatic cancer patients (over 75% in high glucose status and 50% in diabetic status), a peripheral increase of insulin level and exogenous insulin injection can often be seen in PDA cases (Korc, 2007