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When to contact your GP or prescribing clinician: Persistent vomiting preventing adequate hydration or nutrition Severe abdominal pain, particularly if accompanied by fever Signs of pancreatitis (severe upper abdominal pain radiating to the back)stop Wegovy immediately and seek urgent medical assessment Symptoms of gallbladder disease (right upper quadrant pain, jaundice)rapid weight loss increases gallstone risk Inability to tolerate any food or fluids for more than 24 hours Unexplained rapid heart rate or dizziness suggesting dehydration If you have diabetes and take insulin or sulfonylureas: symptoms of hypoglycaemia (sweating, shakiness, confusion) Your prescriber should monitor you regularly as per the SmPC and NICE guidance

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optional extension to 1216 weeks with offperiods [4]

increases the expression of Claudin-1, ZO-1 and Occludin

But if you have severe symptoms, call 911 (or your local emergency number) or go to the nearest emergency room immediately

2ac, Supplementary Materials & Methods Table S2)