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In general, POMC neuron-derived peptides, such as -MSH, can activate the melanocortin-4 receptor (MC4R) in the PVN, which can be inhibited by AgRP released from the AgRP/NPY neurons [16, 17]

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Against this backdrop of investor exuberance, 2024 also delivered a dose of realism to temper runaway excitement about many novel AOM assets purported best-in-class profile, often based on nothing more than limited topline data from phase 1 trials

Therefore, understanding the implications of early pregnancy exposure is critical [70]