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Initially, the neuroprotection of GLP-1RAs was tested in in vivo models of diabetes
As of early 2026, there are 29 pending lawsuits in the NAION MDL attributable to alleged severe eye injuries following semaglutide and tirzepatide use

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Nakamura T., Tanimoto H., Okamoto M., Takeuchi M., Tsubamoto Y., Noda H

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