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The four key mechanisms: Brain appetite centers: Reduces food noise the constant mental preoccupation with food and cravings that many patients describe as their biggest challenge Gastric emptying: Slows how quickly food leaves the stomach, producing prolonged fullness after smaller meals Insulin response: Stimulates insulin release when blood sugar rises improving glucose management without causing low blood sugar on its own Glucagon suppression: Reduces glucagon, a hormone that signals the liver to release stored sugar unnecessarily 2

and (3) conducting patent searches in Orbit Intelligence/Questel, CAS SciFinder, Lens.Org, and the Espacenet (the European Patent Office) databases using (i) keyword based search strings

When will these GLP-1 pills be available

Figure 30: Photograph of Professor Sir Stephen Bloom, 2013, credit: Bloom

These are not medications and there are no known side effects