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This comprehensive analysis confirmed substantial reductions in hepatic fat content measured by MRI-PDFF (weighted mean difference -5.8%, 95%CI: -7.1% to -4.5%), liver enzymes, and histological parameters including steatosis and inflammation scores

Typically, these medications are administered once a week through a subcutaneous injection
Over time, the body may adapt to this state and compensate by taking in more calories, which can offset weight loss
lean mass +2.94%),15 with a clear superiority of SEMA 2.4 mg over LIRA 3 mg (15.8% vs 6.4%) as demonstrated in the STEP 8 study.16 The likelihood of reversal of diabetes by SEMA 2,4 mg was shown to be clearly superior to placebo in the STEP 10 study17 (Table 1)

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