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As a result of these findings, the []

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Depletion of luminal Na+ did not affect l-valine-induced GLP-1 secretion (P>0.05), suggesting that co-transport of l-valine and Na+ is not important for the depolarization necessary to activate the voltage-gated Ca2+-channels

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Here, we explored the signaling pathway involved in the anti-apoptotic effect of GLP-1, and investigated whether metformin had an anti-apoptotic effect on beta cells