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To summarize, GLP-1 drug users can expect to lose an average of 15% to 20% of their weight over the course of a year and four months

J Int Soc Sports Nutr 10(1):6 Li N, Chen S, He Y, Chen Y, Duan X, He W et al (2025) Effects of oral supplementation of beta -hydroxy-beta -methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis

conducted a randomized, double-blind, placebo-controlled Phase 3 trial that evaluated the efficacy and safety of once-weekly tirzepatide (10 mg or 15 mg) in Japanese adults with obesity (BMI 27 kg/m 2 with 2 obesity-related conditions or 35 kg/m 2 with 1, excluding diabetes)

GLP-1 medications produce the opposite effect

Ultimately, exendin-4 may play role as a novel treatment of NAFLD via direct effect on hepatic lipid and glucose metabolism

Thus, in order to have GLP/GIP analogs with lasting effects, alterations of the peptides needed to be made in order to prevent their rapid metabolism by DPP-4 and oral administration could not be used