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Certain microbes ferment fiber into short-chain fatty acids like butyrate, which directly stimulate GLP-1 release from intestinal L-cells and improve glucose control, appetite signaling, and metabolism

those regimens require clinical dose adjustment and monitoring

This indication is appropriate for patients who have not achieved adequate weight loss with lifestyle modifications alone

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However, the most common measurement of food intake was a standardized test meal followed by an ad libitum lunch, dinner, or snack

Journal of Research in Medical Sciences, 17 (12), 11611169