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de Vries ST, Voorham J, Haaijer-Ruskamp FM, Denig P

P2857Increase in Pulse Rate With Semaglutide did Not Result in Increased Adverse Cardiac Events in Subjects With Type 2 Diabetes in the SUSTAIN 6 Cardiovascular Outcomes Trial

However, according to our data, the effectiveness of semaglutide seems to be superior to liraglutide 3.0 mg in post-bariatric WR or IWL

Advise patients and caregivers of the increased risk of suicidal thoughts and behaviors and to immediately report the emergence of new or worsening of depression, suicidal thoughts or behavior, thoughts of self-harm, or other unusual changes in mood or behavior

Consistent follow-up appointments allow for monitoring progress and adjusting the treatment as needed

Accepted reasons for clinical necessity include: Intolerance to GI side effects requires a low-dose titration schedule not available commercially Need for split dosing across two or three weekly injections at doses not available commercially Allergy or sensitivity to an inactive ingredient in the commercial formulation, such as benzyl alcohol, excipients, or preservatives Requirement for a preservative-free formulation Therapeutic-additive requirements, such as leucine, methylcobalamin (B12), pyridoxine (B6), or L-carnitine A specific dose strength or concentration not available in any commercial format An alternative delivery method or dosage form not available commercially The clinical necessity must be explicitly documented on the prescription by the ordering prescriber