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However, balancing the body-weight lowering effect of GCGR agonism with its hyperglycaemic effect is a challenge

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Caution is also needed in those with severe gastrointestinal disease, a history of pancreatitis, or significant psychiatric comorbidity requiring specialist input

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it is only accessible through approved clinical trials, with phase 3 results still awaited as of 2025

13,9,23 Afferent arm Afferent vagus nerve fibres sense peripheral inflammatory molecules and convey signals to the brain and are, therefore, important for immune-to-brain communication (Figure 1)