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However, it was found that the incretin effect remained preserved even after the removal of GIP in experiments

Tirzepatide is a dual agonist at GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors and produces enhanced glycemic control and greater weight loss compared to many GLP-1 RAs [34]

Lactose-free, gluten-free, and sugar-free
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Nausea (28%), diarrhea (23%), constipation (17%), and vomiting (12%) at the 12mg dose are the most commonly reported