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The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery

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Autoimmune thyroid disease (AITD), including Hashimoto thyroiditis and Graves disease, represents the most prevalent organ-specific autoimmunity and a major cause of thyroid dysfunction worldwide