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This was assessed by measuring immature insulin (proinsulin) and reduction in a marker of insulin resistance (HOMA2-IR)

For metformin users, the MHRA recommends periodic monitoring, especially in those with symptoms suggestive of B12 deficiency

Sources Lilly's Mounjaro tops other GLP-1s for some type 2 diabetes patients Reuters May 29, 2026 Tirzepatide Versus Intensified Conventional Care After 2 Years of Treatment in Early Type 2 Diabetes: A Randomized Clinical Trial ACP Journals May 26, 2026 A causal link between autoantibodies and neurological symptoms in long Covid Cell May 28, 2026

What About Retatrutide (Reta) and Endometriosis

Another rare but significant side effect is vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION), sometimes referred to as an eye stroke. This condition can lead to sudden, irreversible blindness