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No premedication was administered before the desensitization

The primary outcome was the incidence of major adverse limb events (defined as either one of the following events: newly diagnosed critical limb ischemia, percutaneous transluminal angioplasty or peripheral bypass of peripheral artery disease, or nontraumatic amputation)

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate beta-cell mitochondrial remodelling and function

Tirzepatide (Mounjaro for diabetes, Zepbound for weight management) is a dual GIP/GLP-1 receptor agonist with similar effects

Cardiorenal protection with the newer antidiabetic agents in patients with diabetes and chronic kidney disease: A scientific statement from the American Heart Association

Then, the dosage increases weekly for five weeks until the maximum dose of 3 mg is reached