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10.1016/j.neuro.2022.08.007 [DOI] [PubMed] [Google Scholar] 81.Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA (2011) GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice
It is key in controlling processes like mitochondrial biogenesis, fatty acid synthesis, and glucose uptake [66], [67]
However, despite significant weight loss, liraglutide-treated animals displayed increased bone mass, trabecular number, and cortical thickness in the appendicular and axial skeletons, with marked improvement in bone formation parameters [5557]

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Importantly, patients prefer, and are more likely to adhere to, an oral drug regimen versus an injectable alternative ( 11 )

Any consideration of investigational approaches should occur only within the context of clinical trials or with explicit acknowledgment of the limited evidence base and careful risk-benefit assessment tailored to your specific clinical circumstances
