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Fen-phen was marketed as an effective weight loss drug in the 1990s but later pulled from the market due to its link to severe heart and lung problems, including pulmonary hypertension and heart valve damage

This altered composition could be the result of gut microbiota dysbiosis, like that observed in IBD patients, and contributes to the development of intestinal inflammation [25]

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Scenario 2: Someone tries to calculate a 1,000mcg dose but is confused by the 0.1mL result

A single skin administration of a PSR-MNs patch (2 cm 2 cm) which contains 4 programmable core-shell MNs patches (1 cm 2 each, so-called pixels) enables the repeated release of Semaglutide every 7 days and sustains the drug efficacy for an unprecedented one-month period, simulating the effect of using four bolus injections spaced 7 days apart