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Central and peripheral GLP-1 systems independently suppress eating

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16 This approval was based on a randomized, double-blind, placebo-controlled trial of 701 patients inadequately controlled on metformin alone

Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

Am J Obstet Gynecol 198(6):611619 Lee KK, Raja EA, Lee AJ, Bhattacharya S, Norman JE, Reynolds RM (2015) Maternal obesity during pregnancy associates with premature mortality and major cardiovascular events in later life

Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication