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Additionally, reduced sodium intake associated with healthier eating patterns may decrease fluid retention, leading to increased urination as excess fluid is eliminated

[PUBMED Abstract] Pienta KJ, Redman B, Hussain M, et al.: Phase II evaluation of oral estramustine and oral etoposide in hormone-refractory adenocarcinoma of the prostate

Patients should be informed about symptoms like severe abdominal pain (a sign of pancreatitis), persistent nausea or vomiting, and any unusual changes in heart rate or blood sugar levels

Risk of Bias Assessment The Cochrane risk of bias tool was used to assess the quality of the articles included in the analysis (Supplementary appendix A)

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