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Reciprocally, hypolocomotion can be systematically observed in SPF mice (presence of microbiome) subjected to agonism of GLP-1R and neural modulation of DVC by FUS

Collectively, these findings provide a mechanistic rationale for developing multi-target agonists: GLP-1R appears to provide the most potent and direct anti-MASLD and anti-fibrotic effects in the liver, while GIPR and GCGR offer complementary benefits for glucose and lipid metabolism, with GIPR also exhibiting superior cardiovascular protection

Kaptiza C, Nosek L, Jensen L, Hartvig H, Jensen CB, Flint A

August 2025, modified September 2025): Recent evidence has transformed our approach to MASH with fibrosis (stage 2)

Equipment: Always use a sterile, single-use insulin syringe for accurate measurement and hygiene

Journal of Nutrition
