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Fass R, Pieniaszek HJ, Thompson JR
Not everyone will need the maximum dose

Diabetologia 61:284294
This was evidenced by significantly elevated levels of the pro-inflammatory lipid 9,10-DiHOME (8.0-fold), the oxidative stress marker glutathione disulfide (1.8-fold), and downstream products of the tryptophan-kynurenine inflammatory pathway, namely quinolinic acid (5.0-fold) and indole (4.0-fold)

Adverse effects vary by molecule, dose, and patient sensitivity
