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There's another theory as to why GLP-1s (glucagon-like peptide-1 receptor agonists) the class of medication semaglutide belongs to can cause nausea

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In certain amounts, prebiotic fiber can activate the release of GLP-1 (Glucagon-Like Peptide-1), a hormone that helps regulate appetite, slow stomach emptying, and promote feelings of fullness

Moreover, Exendin-4 significantly increases A-induced decrease in mitochondrial function, integrity and respiratory control rate in all brain regions (189)

Glucagon-Like Peptide-1 Receptor Agonists for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: A Meta-Analysis
The consistency of results across diverse patient populations reinforced its legitimacy as a serious therapeutic option rather than a trend