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FDA-approved GLP-1 medications are available in injectable form (weekly subcutaneous injections, like Wegovy and Zepbound) and oral form (daily tablets, like Wegovy oral and the newly FDA-approved Foundayo, which contains orforglipron)

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Retatrutide is a 39-amino-acid peptide coupled to a fatty diacid moiety

Upon activation, the receptor triggers intracellular signaling cascades, mainly via cyclic adenosine monophosphate (cAMP) production and protein kinase A (PKA) activation

The cardiovascular disease status of the patients differed in the studies and may have influenced the heart failure outcome (57)