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Safety is always the primary concern when combining medications

STEP 4 (withdrawal study): People who stopped semaglutide after 20 weeks regained an average of 6.8% body weight within the following year, confirming that both the drugs side effects and its benefits reverse after stopping

Concerns include early treatment adjustment effects, individual sensitivity, and overlapping metabolic or psychological factors

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The optic nerve is known to host receptors that semaglutide can attach to, but the current research did not adequately address all the confounding factors that could be playing a role in the association

This approach also reduces the load placed on a slower-moving digestive system