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95% CI, 1.432.20 for SGLT2i versus SGLT2i plus GLP-1RA) and GLP-1RA monotherapy (HR, 2.11

These metabolic improvements matter enormously for long-term health outcomes

These reductions in fat mass, lean body mass, and muscle mass correlate with the degree of body weight reduction and are similar to those documented with other obesity therapies that achieve large weight reductions, such as bariatric surgery and very low-calorie restricted diets [61]

Researchers estimate that covering obesity treatments under Medicare could save the program $175 billion over 10 years by reducing the costs of obesity-related diseases

The FDA issued warning letters in September 2025 related to GLP-1 distribution practices

Tirzepatide exerts its therapeutic effects through dual agonism of two key incretin receptors: the GIPR and the GLP-1R