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Key Differences Summary# Conclusion# Semaglutide is the established standard of care with an unmatched evidence base in metabolic therapeutics

The STRIDE trial also showed that semaglutide led to a greater estimated median ratio to baseline in maximum walking distance at week 52 than the placebo among people with symptomatic peripheral artery disease and T2D [14]

There is currently no approved pharmacy or prescription pathway for retatrutide anywhere in the world

Biosimilar applicants must conduct extensive analytical comparisons, and often clinical pharmacology and clinical studies, to establish biosimilarity

Multivariate analysis of fasting glucose showed that fasting glucose was lower in the placebo arm at 12 months (2.2 mmol/L 95%CI: 0.4, 4.1, p = 0.027) but not at 6 months (1.4 mmol/L, 95%CI 1.1, 3.9, p = 0.24) (Supplementary Tables 10.1 and 10.2)