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There is a plausible risk that the glucose-raising effects of tesamorelin could blunt some of the glycaemic benefits of retatrutide

However, there are important caveats: The interim analysis was at 72 weeks

If you develop severe vomiting or dehydration while taking both medications, contact your healthcare provider promptly, as they may recommend temporarily pausing semaglutide until you recover

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Tirzepatide works by mimicking two natural hormones in the body, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

If you have a history of allergies or have experienced allergic reactions to medications in the past, be sure to inform your doctor before starting semaglutide or any new treatment to minimize the risk of potential allergic responses