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The three most common active ingredients used in GLP-1s are semaglutide, liraglutide, and tirzepatide

However, current evidence is limited, and the proposed mechanisms and behavioral implications require empirical testing

Fracture Risk Data from GLP1 Trials Several cardiovascular outcomes trials (CVOTs) have collected fracture data as secondary outcomes: Trials involving semaglutide and dulaglutide generally report fracture rates similar to placebo A few studies suggest a potential increase in non-vertebral fractures, though findings are inconsistent and often not statistically significant One important confounder is weight loss, which itself can lead to bone loss

Patients can count clicks to use smaller doses of semaglutide

For many people, happiness about their breakthrough weight loss arrives mixed with something akin to grief
