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Insulin resistance adds an additional layer of vulnerability

Mood and appetite, he explained, are closely related (think of stressful eating or eating when we are sad, comfort food), and a benefit of [GLP-1 drugs] is that they help control appetite and satiety, which allows patients to make better meal choices and become healthier. So, the modest improvement in depression seen in the study may be related to weight loss, improved blood sugars, [fewer diabetes] symptoms, and likely an overall sense of patients getting healthier, Splenser hypothesized

Adequate protein intake is one of the most evidence-supported strategies for preserving muscle during caloric restriction

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While also underpowered to detect clinical events, there was a signal noted towards reduction of the first HF event (HR 0.40

Preclinical data strongly map these peptides to enhanced barrier function, mucosal proliferation, and local immunomodulation