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Willis M, Fridhammar A, Gundgaard J, et al

The risk is not universalgenetic factors, baseline uric acid levels, and individual metabolic responses determine who develops clinically significant hyperuricemia
Individual variation is significantsome patients feel profound appetite suppression immediately, while others experience gradual changes over weeks

10.1016/j.physbeh.2014.01.015 [DOI] [PMC free article] [PubMed] [Google Scholar] Kreisler, A

The starting dose is a 1.5mg tablet once a day for one month and then, after consultation, the dose would generally increase each month until the recommended maximum dose of 25mg once a day

doi: 10.2174/1381612826666200523180301