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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Wei L., Gao J., Wang L., Tao Q., Tu C

If you are dealing with constipation on tirzepatide that fiber supplements have not resolved, low potassium could be the underlying cause
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However, some patients report muscle tightness, aches, or cramping during real-world use

These effects are likely mediated through modulation of the brains reward system and gutbrain axis
