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Pathophysiological factors such as ischemia, hypoxia, oxidative stress, or calcium homeostasis disorders can disrupt endoplasmic reticulum homeostasis, cause endoplasmic reticulum dysfunction, and lead to the accumulation of unfolded or misfolded proteins, thus inducing ERS and triggering unfolded protein response, thereby activating the corresponding endoplasmic reticulum and calcium regulatory mechanisms and other signal transduction pathways to restore endoplasmic reticulum homeostasis

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Trulicity (Dulaglutide): A once-weekly injection FDA-approved for the treatment of type 2 diabetes Victoza (Liraglutide): A once-daily injection FDA-approved for the treatment of type 2 diabetes and the risk of cardiovascular events in people with type 2 diabetes