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Lilly produced a drug that is a combination of a GLP analogue and a GIP analogue, which breaks apart in the system and hits both receptors. There are indications that the dual approach is synergistic

You can read the abstract of this article at In a Phase 3 trial involving 1879 individuals with type 2 diabetes (T2D) on metformin, Tirzepatide (TZP) at doses of 5 and 15 mg demonstrated substantial improvements in HbA1c and weight reduction compared to 1 mg of semaglutide (SEMA)

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The dual-receptor action of tirzepatide may produce more pronounced gastric effects in some individuals, which could translate to higher heartburn rates