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Trials excluded patients with prediabetes, and the abovementioned observational studies included patients with higher HbA1c levels at baseline, affecting the comparability

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doi: 10.1210/endo.142.3.8034

The exclusive expression of GCG in pancreatic -cells, enteroendocrine L cells, and some neurons in the brainstem underlines its pivotal role (57)
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Follow-up Duration : While trials extend to 72 weeks or longer, the chronic nature of obesity requires decades-long, unavailable safety and efficacy data