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All GLP-1 receptor agonists and tirzepatide carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Extreme temperatures can degrade the medication

these should be taken 30 minutes before eating a meal

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A phase 2 study in persons with biopsy-proven NASH using a daily injection equivalent to semaglutide 2.4 g/week demonstrated 13% weight loss and improvement in hepatic fibrosis stage in 43% of participants compared to 1% weight loss and 33% fibrosis score improvement with placebo