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[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Gerstein H.C., Colhoun H.M., Dagenais G.R., Diaz R., Lakshmanan M., Pais P

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10.1007/BF02427280 6

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

Compared to classical exenatide given twice daily (BID, the once-weekly (QW) formulation at a 2 mg dose level provides a relatively stable plasma concentration at steady-state (300 pg/ml) because of the more continuous delivery of the drug, with equal (or slightly improved) efficacy on glycemic control and body weight after 24 and 30 wk of treatment [888]