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One of the reasons that Wegovy has attracted so much attention is because it is markedly more effective than any previous weight-loss therapeutics to have reached the UK market, such as: Orlistat blocks the intestinal absorption of fat by a third Dr Varadarajan Baskar, clinical lead at the Birmingham-based Weight Loss Clinic and an endocrinologist at the South Warwickshire NHS Foundation Trust, explains that before GLP-1 drugs emerged, the only weight-loss medication approved on the NHS was orlistat